25 ta’ Mar 2025 · Certain cytokines such as IL-3, IL-6, IL-11, LIF, erythropoietin, and thrombopoietin all stimulate the maturation of megakaryocytic progenitor cells. [9] Other signals such as PF4, CXCL5, CXCL7, and CCL5 inhibit platelet formation. [10]

巨核细胞（Megakaryocyte）是骨髓中的一种从造血干细胞分化而来的细胞，是正常骨髓中的一种能生成血小板的成熟细胞，前身为颗粒巨核细胞。该细胞体积巨大，成熟的巨核细胞边缘部分破裂脱落后形成血小板。平均每个巨核细胞能生成2000个（200～7700个）血小板。它的核虽然很大，但其数量非常少 ...

18 ta’ Diċ 2020 · In total, 9,485 and 9,672 cells were captured on days 12+0 and 12+6 of megakaryocytic differentiation, respectively; these populations contained MKs, Erys, and Macs that were identified based on their expression of known marker genes, confirmed by morphological examination (Figures 5B, 5C, and S4A–S4G; Tables S2E, S2F, S5A, and S5B).

30 ta’ Ott 2023 · Megakaryocytes are a special type of bone marrow cells that give rise to thrombocytes (platelets). These cells are large and measure about 50–150 µm in diameter and are usually found near sinusoidal capillaries of the bone marrow.

10 ta’ Apr 2024 · 近日，南方医科大学基础医学院李专课题组在The EMBO Journal（一区，IF 11.4）上发表了题为“A subset of megakaryocytes regulates development of hematopoietic stem cell precursors”的研究论文。该研究揭示了胚胎巨核细胞作为微环境调控因子 ...

Single-cell RNA sequencing studies have revealed transcriptional heterogeneity within the megakaryocytic lineage and the identified unique subsets. In this review, we discuss the functional and phenotypic plasticity of these subpopulations as well as the impacts on health and disease. Recent findings:

1 ta’ Jan 2019 · Recent studies using clonal in vitro assays and in vivo clonal tracking programs have distinguished cells within immunophenotypically delineated HSCs or their direct committed progeny that have restricted megakaryocytic potential. 2 These experiments have led to a new model of megakaryocyte development and new ideas surrounding the ...

The concept of a megakaryocytic niche arose from the finding that approximately a fifth of HPSCs were associated with megakaryocytes independent from an arteriole. Megakaryocytes promote HSPC quiescence through expression of CXCL4 and TGFβ (Bruns et al., 2014).

2 ta’ Mej 2019 · Megakaryocyte-biased HSCs, as defined by high CD41 expression, high c-Kit expression, or VWF expression, are also enriched for megakaryocytic transcription factors such as GATA1, GFI1b, GATA2, and FLI1, suggesting that HSC megakaryocyte bias may occur at the transcriptional level before differentiation. 18,20,30 This is further supported by ...

Zhang J, Varas F, Stadtfeld M, Heck S, Faust N, Graf T. CD41-YFP mice allow in vivo labeling of megakaryocytic cells and reveal a subset of platelets hyperreactive to thrombin stimulation. Experimental hematology. 2007;35(3):490–499.